In Vitro Diagnostics Products & Technologies |
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Frequently Asked Questions - PreservativesIs there a preservative in the Stabilization Products?No preservatives are added to StabilCoat & 5X StabilCoat Stabilizers or to StabilGuard Stabilizer. If you would like to add a preservative to either or these products, we recommend using ProClin™ at the manufacturer's recommended use concentration. However, a mercury- and azide-free preservative is added to the following Stabilization Products: StabilCoat Plus Microarray Stabilizer The preservative is a mixture of bromonitrodioxane and methylisothiazolone (Micr-O-Protect). Do you have any data showing the efficacy of preservative used in the StabilZyme stabilizers, StabilCoat Plus or StabilGuard Choice stabilizers?An antimicrobial is used in the formulation of SurModics stabilization products to preserve their biological integrity. We do not make any further claims for antimicrobial efficacy once the product is in use. During development of the products, Antimicrobial Preservative Effectiveness was performed. A summary of the results may be requested from Customer Service.
The following is a link to the product insert for the antimicrobial (Microprotect) used. https://www.roche-applied-science.com/pack-insert/1585720a.pdf. The second page outlines recommended concentrations; the antimicrobial concentration of the StabilZyme products (and StabilCoat Plus and StabilGuard Choice Stabilizers) is at 0.2%. Be sure that you do not dilute the stabilizers to a point below the low end of the antimicrobial's efficacy. Can Thimerosal be added to the Stabilization Products?Yes. You may use a concentration of 0.01-0.05%. Can Sodium Azide be added to the Stabilization Products?Sodium azide interferes with horseradish peroxidase (HRP). However, since the preservative is most likely washed out after blocking or during the assay, this should not be a concern. Of course, this should be tested in your system to ensure desired results. Back to FAQs
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