Welcome to the second in a series of quarterly newsletters from SurModics. As a top provider of high-quality assay components to the in vitro diagnostics industry, we offer a complete line of immunoassay, conjugate, and microarray stabilizers; BioFX-brand colorimetric and chemiluminescent substrates; autoimmune antigens from DIARECT AG; and secondary antibodies.

Introducing BioFX-Brand Substrates

As you may already know, in August 2007 SurModics acquired BioFX Laboratories to broaden our product and technology offerings to the in vitro diagnostics market. BioFX is a leading manufacturer of colorimetric and chemiluminescent substrates, and a supplier of innovative immunoreagents to the biomedical research and medical diagnostic markets. BioFX has a history of commitment to innovation, quality, performance, and technical service. Described below are a few examples of the many new products we now offer as part of our BioFX-brand portfolio. Click here to download a Substrate Overview Table.

BioFX-Brand Chemiluminescent Substrates

HRP Chemiluminescent Substrates
Designed to meet all of your sensitivity needs for both microwell and membrane applications. These two-component formulations produce a glow reaction that offers a 100-fold improvement in signal-to-noise ratio over existing luminol formulations. (Learn More)

AP Chemiluminescent Substrates
With five unique AP Chemiluminescent substrates, we can meet all of your sensitivity needs for both microwell and membrane applications. These one-component dioxetane-based formulations are sensitive to the attogram to nanogram level and allow for readings at both 450 nm and 540 nm. (Learn More)

BioFX-Brand Colorimetric Substrates

For Microwell Applications
TMB HRP Substrates
Six one-component kinetic options are available to meet your colorimetric needs for microwell applications. BioFX-brand TMB formulations offer extraordinary sensitivity, stability, and consistency and are available in one-component, two-component, and powder formulations. (Learn More)

ABTS HRP Substrate
A one-component ABTS substrate for microwell applications, plus an available ABTS enhancer that can increase the sensitivity of your assay by up to 80%. (Learn More)

pNPP AP Substrate
This pNPP colorimetric substrate offers a unique, patented, one-component option for your microwell applications. While many pNPP products turn yellow at room or elevated temperatures, BioFX-brand pNPP substrate includes stabilizing pellets that retain activity even after the rigors of international shipping and room-temperature storage. (Learn More)

Stop Reagents for HRP and AP Substrates
Both powder and liquid formulations that can efficiently and effectively stop TMB, ABTS, pNPP, and AP-Blue & AP-Red microwell reactions. (Learn More)

For Membrane Applications
TMB Substrates
Two unique, one-component, ready-to-use TMB substrates for the detection of peroxidase in membrane applications are highly sensitive, high-performance formulations that produce an increased signal-to-noise ratio and low membrane background. (Learn More)

DAB TMB Substrate
A two-component liquid formulation for the rapid and simple detection of peroxidase in membrane applications that offers increased stability and greatly improved sensitivity. (Learn More)

BCIP/NBT AP Substrates
Two unique, one-component, ready-to-use BCIP/NBT substrates for the detection of alkaline phosphatase in membrane applications are available in blue or purple, and provide crisp detail and low background.
(Learn More)

AP-New Magenta Substrate
A stable, liquid, three-component substrate that produces a permanent intense red reaction in membrane blotting applications containing alkaline phosphatase. (Learn More)

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In addition to offering high-quality assay components to the in vitro Diagnostics industry, SurModics is a leading provider of surface modification and drug delivery solutions for medical-device and biomedical applications. Visit SurModics’ corporate web site at www.surmodics.com for more information.