In Vitro Diagnostic Products
*Samples not available for some products.
Even though radioimmunoassays (RIAs), which use radioactive labels, have been largely replaced by ELISAs (using colorimetric substrates), they still offer researchers some advantages, such as increased sensitivity. RIAs were first developed to measure small concentrations of hormones in blood. The basic principle of a radioimmunoassay involves a known quantity of antigen (e.g., hormone) that is radioactively labeled and mixed together with a known amount of antibody to that antigen. A sample of patient serum, which has an unknown quantity of the antigen, is then added.The two antigens (radioactively labeled and the patient’s) compete for antibody binding sites. A binding curve can then be plotted and the amount of antigen in the patient’s serum determined.
SurModics’ StabilCoat® Immunoassay Stabilizer and StabilGuard® Immunoassay Stabilizer (BSA-Free) are effective for stabilizing the activity of the protein portions of RIA, producing more reliable and consistent results.
StabilZyme SELECT® and StabilZyme® NOBLE Stabilizers are useful for stabilizing the serum controls often utilized in RIAs.